Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
نویسندگان
چکیده
منابع مشابه
Leukocyte telomere length and cardiovascular disease in the cardiovascular health study.
The telomere length of replicating somatic cells is inversely correlated with age and has been reported to be associated cross-sectionally with cardiovascular disease (CVD). Leukocyte telomere length, as expressed by mean terminal restriction fragment (TRF) length, was measured in 419 randomly selected participants from the Cardiovascular Health Study, comprising a community-dwelling cohort rec...
متن کاملOriginal Contribution Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
1 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 2 Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 3 Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, Newark, NJ. 4 Department of Medicine, School of Medicine, University ...
متن کاملPhysical Activity, Physical Fitness, and Leukocyte Telomere Length: The Cardiovascular Health Study.
INTRODUCTION The influence of physical activity (PA) and physical fitness (PF) at older ages on changes in telomere length (TL)--repetitive DNA sequences that may mark biologic aging--is not well-established. Few prior studies (mainly cross-sectional) have been conducted in older adults, and few studies have evaluated PF. METHODS We investigated cross-sectional and prospective associations of...
متن کاملInsulin-like growth factors and leukocyte telomere length: the cardiovascular health study.
The insulin-like growth factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IG...
متن کاملCellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk.
OBJECTIVE To determine the association between leukocyte telomere length (TL) and atherosclerosis and its clinical sequelae stroke and myocardial infarction. METHODS AND RESULTS Within the scope of the prospective population-based Bruneck Study, leukocyte TL was measured by quantitative polymerase chain reaction in 800 women and men aged 45 to 84 years (in 1995). The manifestation of cardiova...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2006
ISSN: 0002-9262,1476-6256
DOI: 10.1093/aje/kwj346